Boehm D, Conrad R, Ott M (2013). Viruses 5:1571–1586. doi: 10.3390/v5061571
Publication Category: HIV/AIDS
Three rules for HIV latency: location, location, and location.
Ott M, Verdin E (2013). Cell Host Microbe 13:625–626.
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li P-C, Planelles V, Bradner JE, Zhou M-M, Siliciano RF, Weinberger L, Verdin E, Ott M (2013). Cell Cycle 12:452–462.
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.
Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnolzer M, Verdin E, Zhou M-M, Ott M (2012). J Biol Chem 287:1090–1099.
The Control of HIV Transcription: Keeping RNA Polymerase II on Track.
Ott M, Geyer M, Zhou Q (2011). Cell Host Microbe 10:426–435.
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).
Sakane N, Kwon H-S, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M (2011). PLoS Pathog 7:e1002184.
HIV never ceases to surprise: Innovative methods in the quest for a cure.
Ott M (2011). Methods 53:1–2.
https://doi.org/10.1016/j.ymeth.2010.12.038
Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies.
Pagans S, Sakane N, Schnolzer M, Ott M (2011). Methods 53:91–96.
https://doi.org/10.1016/j.ymeth.2010.07.001
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M (2010). Cell Host Microbe 7:234–244.
Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.
Cho S, Schroeder S, Kaehlcke K, Kwon H-S, Pedal A, Herker E, Schnoelzer M, Ott M (2009). EMBO J 28:1407–1417.