The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

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Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

Taha TY, Ezzatpour S, Hayashi J, Ye Chengjin, Zapatero-Belinchon FJ, ROsecrans JA, Kimmerly GR, Kimmerly GR, Chen IP, Walcott K, Kurianowicz, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Martinez-Sobrino L, Aguilar HC, Ott M.

[Preprint] 2024, December 30. 2024.12.30.628795; doi: https://doi.org/10.1101/2024.12.30.628795

Fibrin drives thromboinflammation and neuropathology in COVID-19.

Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K.

 

2024 Sep;633(8031):905-913. doi: 10.1038/s41586-024-07873-4. Epub 2024 Aug 28. PMID: 39198643; PMCID: PMC11424477.

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR.

 

2024 Aug 2;10(31):eadm8836. doi: 10.1126/sciadv.adm8836. Epub 2024 Jul 31. PMID: 39083602; PMCID: PMC11290487.