Sonali Chaturvedi, Gustavo Vasen, Michael Pablo, Xinyue Chen, Nathan Beutler, Arjun Kumar, Elizabeth Tanner, Sylvia Illouz, Donna Rahgoshay, John Burnett, Leo Holguin, Pei-Yi Chen, Blaise Ndjamen, Melanie Ott, Robert Rodick, Thomas Rogers, David M. Smith, Leor Weinberger, Identification of a Therapeutic Interfering Particle — a single-administration SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Cell, 2021, https://doi.org/10.1016/j.cell.2021.11.004.
Archives: Publications
Publications
Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles
Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen P-Y, Hayashi JM, Soczek KM, Ott M, Doudna JA. Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles. Science.0(0):eabl6184. doi: doi:10.1126/science.abl6184.
Accelerated RNA detection using tandem CRISPR nucleases
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ; IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Accelerated RNA detection using tandem CRISPR nucleases.
doi: 10.1038/s41589-021-00842-2
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2
Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA.
doi: 10.1021/acsinfecdis.1c00017.
Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus
Sensitive and multiplexed RNA detection with Cas13 droplets and kinetic barcoding
Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA
Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA.
doi: 10.1016/j.jviromet.2021.114115.
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi JM, Simoneau CR, Kumar GR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Frankino PA, Shivram H, Lareau LF, Wyman SK, Ott M, Andino R, Chiu CY.
doi: 10.1016/j.cell.2021.04.025.
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M.
doi: 10.1038/s41598-021-91625-1
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator
Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP.
doi: 10.1101/2021.06.01.446640.