The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

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Catching BETs by viruses

Mohamad Zandian, Irene P. Chen, Siddappa N. Byrareddy, Danica Galonić Fujimori, Melanie Ott, Tatiana G. Kutateladze, Catching BETs by viruses. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, 2022, https://doi.org/10.1016/j.bbagrm.2022.19485

Neutralizing antibody activity against SARS-CoV-2 variants in gestational age–matched mother-infant dyads after infection or vaccination

Matsui Y, Li L, Prahl M, Cassidy A, Ozarslan N, Golan Y, Gonzalez V, Lin C, Jigmeddagva U, Chidboy M, Montano M, Taha T, Khalid M, Sreekumar B, Hayashi J, Chen P, Kumar G, Warrier L, Wu A, Song D, Jegatheesan P, Rai D, Govindaswami B, Needens J, Rincon M, Myatt L, Asiodu I, Flaherman V, Afshar Y, Jacoby V, Murtha A, Robinson J, Ott M, Greene W, Gaw S. Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination. JCI Insight. 2022 . doi: 10.1172/jci.insight.157354. 

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M.  Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. Nature. 2022.  doi: 10.1038/s41586-022-04865-0. 

Tropism of SARS-CoV-2 for human cortical astrocytes

Andrews G.A, Mukhtar T, Eze U.C, Simoneau C.R, Perez Y, Mostajo-Radji M.A, Wang S, Velmeshev D, Jahan S, Kumar G.R, Pollen A.A, Crouch E, Ott M, Kriegstein A.R. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. Proc Natl Acad Sci U S A . 2022   doi: 10.1073/pnas.2122236119

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J Jr, Andino R, Wadford DA, Hanson C*, Doudna J,* Ott M*, Chiu CY*. Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Cell. 2022. doi: 10.1016/j.cell.2022.03.019.

Hydration for Clean Air Today

Edwards DA, Norden B, Karnath L, Yaghi O, Roy CJ, Johanson D, Ott M, Brownstein J, Grove J, Tomson G, Friberg P  Hydration for Clean Air Today. Mol Front J. 2022. doi: 10.1142/S252973252101001X.

Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2

Chen I, Longbotham J.E, McMahon S, Suryawanshi R, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg F.W , Hayashi J.M , Taha T.H, Lam V.L, Li Y, Yu Z, Titus E.W, Diallo A,  Oki J, Holden K, QCRG Structural Biology Consortium; Krogan N, Fujimori D, Ott MViral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. Cell Rep. 2022.  doi: 10.1016/j.celrep.2022.111088. Epub 2022 Jun 27