Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M (2005). Plos Biol 3:e41.
Publication Category: HIV/AIDS
HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.
Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D’Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS (2004). Mol Cell 13:179–190.
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.
Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou M-M, Verdin E (2004). Novartis Found Symp 259:182–93– discussion 193–6– 223–5.
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M (2003). Mol Cell 12:167–176.
Acetylation of the HIV-1 Tat protein: an in vitro study.
Dormeyer W, Dorr A, Ott M, Schnolzer M (2003). Anal Bioanal Chem 376:994–1005.
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
Dorr A, Kiermer V, Pedal A, Rackwitz H-R, Henklein P, Schubert U, Zhou M-M, Verdin E, Ott M (2002). EMBO J 21:2715–2723.
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou M-M (2002). Mol Cell 9:575–586.
HIV-1 protein Tat reduces the glutamate-induced intracellular Ca2+ increase in cultured cortical astrocytes.
Köller H, Schaal H, Freund M, Garrido SR, von Giesen HJ, Ott M, Rosenbaum C, Arendt G.
Eur J Neurosci. 2001 Dec;14(11):1793-9. doi: 10.1046/j.0953-816x.2001.01808.x. PMID: 11860474.
Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity.
Ott M, Schnolzer M, Garnica J, Fischle W, Emiliani S (1999). Curr Biol 9:1489-92.
Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors.
Ott M, Lovett JL, Mueller L, Verdin E.
J Immunol. 1998 Mar 15;160(6):2872-80. PMID: 9510190.