The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

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Catching BETs by viruses.

Mohamad Zandian, Irene P. Chen, Siddappa N. Byrareddy, Danica Galonić Fujimori, Melanie Ott, Tatiana G. Kutateladze, Catching BETs by viruses. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, 2022, https://doi.org/10.1016/j.bbagrm.2022.19485

Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2.

Chen I, Longbotham J.E, McMahon S, Suryawanshi R, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg F.W , Hayashi J.M , Taha T.H, Lam V.L, Li Y, Yu Z, Titus E.W, Diallo A,  Oki J, Holden K, QCRG Structural Biology Consortium; Krogan N, Fujimori D, Ott MViral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. Cell Rep. 2022.  doi: 10.1016/j.celrep.2022.111088. Epub 2022 Jun 27

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.

Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M.  Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. Nature. 2022.  doi: 10.1038/s41586-022-04865-0.