Publications Archive : The Ott Lab

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.

Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M.

14(1):15351. doi: 10.1038/s41598-024-66003-2. PMID: 38961189; PMCID: PMC11222426.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

Zhao H, Syed AM, Khalid MM, Nguyen A, Ciling A, Wu D, Yau WM, Srinivasan S, Esposito D, Doudna JA, Piszczek G, Ott M, Schuck P.
2024 Jun 24;52(11):6647-6661. doi: 10.1093/nar/gkae256. PMID: 38587193; PMCID: PMC11194069.

Colloidal aggregation confounds cell-based Covid-19 antiviral screens

Glenn IS, Hall LN, Khalid MM, Ott M, Shoichet BK.

2024 Jun 12. doi: 10.1021/acs.jmedchem.4c00597. Epub ahead of print. PMID: 38864383.

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.

Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng’ Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ.
2024 Feb 27:e0222223. doi: 10.1128/mbio.02222-23. Epub ahead of print. PMID: 38411080.

De novo-designed minibinders expand the synthetic biology sensing repertoire

Weinberg ZY, Soliman SS, Kim MS, Chen IP, Ott M, El-Samad H.

2024 Jan 15:2024.01.12.575267. doi: 10.1101/2024.01.12.575267. PMID: 38293112; PMCID: PMC10827046.

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination

Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Kumar GR, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Kojima N, Arellanor T, Bussanich A, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Wang Y, Ghazarian S, Davis G, Rodriguez D, Doudna J, Spraggon L, Chiu CY, Ott M.
2023 Dec;12(2):2270071. doi: 10.1080/22221751.2023.2270071. Epub 2023 Oct 31. PMID: 37869789; PMCID: PMC10619466.

Protocol for an in vitro assay to study HIV-1 Tat methylation

Boehm D, Kaehlcke K, Schnoelzer M, Ott M.
2023 Nov 17;4(4):102687. doi: 10.1016/j.xpro.2023.102687. Epub ahead of print. PMID: 37979180.

Hepatitis C virus infects and perturbs liver stem cells

Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, McDevitt TC, Yosef N, Ott M.
2023 Nov 8:e0131823. doi: 10.1128/mbio.01318-23. Epub ahead of print. PMID: 37938000.

A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells

Boehm D, Ott M.
STAR Protoc. 2023 Nov 4;4(4):102694. doi: 10.1016/j.xpro.2023.102694. Epub ahead of print. PMID: 37925635.

HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing

Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O’Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M.
2023 Oct 28;15(11):2171. doi: 10.3390/v15112171. PMID: 38005849; PMCID: PMC10674359.

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