The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

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Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Parthasarathy H, Gordon M, Malpotra S, Cupic A, Kehrer T, Dos Santos M, Benjamin R, Moen JM, Winters DM, Caval V, Rojc A, Mena I, Aslam S, Martinez-Romero C, Viñas IC, Khalil Z, Farrugia K, Villalón-Letelier F, Banerjee A, Tussia-Cohen D, Diallo A, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, San Felipe CJ, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi RK, Bonaventure B, Ibáñez C, Johnson JR, Juste J, Pache L, Stroud RM, Verba KA, Fraser JS, van Bakel H, Taha TY, Ott M, Hagai T, Jouvenet N, Demeret C, Polacco BJ, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ.

S1931-3128(26)00171-X. doi: 10.1016/j.chom.2026.04.015. Epub ahead of print. PMID: 42134328.

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

Khalid, M. M., Chen, I. P., Soveg, F. S., Taha, T. Y., Tabata, T., Suryawanshi, R. K., Syed, A. M., Ciling, A., McCavitt-Malvido, M., Schulze-Gahmen, U., Hayashi, J., Kim, I. J., Fong, S. W., Batra, J., Kumar, G. R., Renia, L., Ng, L. F., Krogan, N. J., Doudna, J. A., Verdin, E., … Ott, M. (2026).

bioRxiv : the preprint server for biology, 2024.03.05.583578. https://doi.org/10.1101/2024.03.05.583578

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

Lizzadro, L., Li, J., Taha, T. Y., Degotte, G., Detomasi, T. C., Zapatero-Belinchon, F. J., Hantz, E. R., Huang, S., Matsui, Y., Henderson, W. R., McCann, J. T., Montano, M., Rosecrans, J., Torres Pomares, D. F., McGovern, B. L., Diaz-Tapia, R., Benjamin, J., Gordon, M. E., Suazo, I. D., Settineri, N. S., … Renslo, A. R. (2026).

Journal of medicinal chemistry, 69(2), 1530–1551. https://doi.org/10.1021/acs.jmedchem.5c03015

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Suryawanshi, R. K., Jaishankar, P., Correy, G. J., Rachman, M. M., O’Leary, P. C., Taha, T. Y., Matsui, Y., Zapatero-Belinchón, F. J., McCavitt-Malvido, M., Doruk, Y. U., Stevens, M. G. V., Diolaiti, M. E., Jogalekar, M. P., Chen, H., Richards, A. L., Kongpracha, P., Bali, S., Montano, M., Rosecrans, J., Matthay, M., … Fraser, J. S. (2025).

eLife, 14, RP103484. https://doi.org/10.7554/eLife.103484

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

Jaishankar, P., Correy, G. J., Matsui, Y., Togo, T., Rachman, M. M., Stevens, M. G. V., Hantz, E. R., Zheng, J., Diolaiti, M. E., Montano, M., Taha, T. Y., Rosecrans, J., Pampel, J., Krogan, N. J., Shoichet, B. K., Ashworth, A., Ott, M., Fraser, J. S., & Renslo, A. R. (2025).

bioRxiv : the preprint server for biology, 2025.10.11.681833. https://doi.org/10.1101/2025.10.11.681833