The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

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Neutralizing antibody activity against SARS-CoV-2 variants in gestational age–matched mother-infant dyads after infection or vaccination

Matsui Y, Li L, Prahl M, Cassidy A, Ozarslan N, Golan Y, Gonzalez V, Lin C, Jigmeddagva U, Chidboy M, Montano M, Taha T, Khalid M, Sreekumar B, Hayashi J, Chen P, Kumar G, Warrier L, Wu A, Song D, Jegatheesan P, Rai D, Govindaswami B, Needens J, Rincon M, Myatt L, Asiodu I, Flaherman V, Afshar Y, Jacoby V, Murtha A, Robinson J, Ott M, Greene W, Gaw S. Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination. JCI Insight. 2022 . doi: 10.1172/jci.insight.157354. 

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M.  Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. Nature. 2022.  doi: 10.1038/s41586-022-04865-0. 

Tropism of SARS-CoV-2 for human cortical astrocytes

Andrews G.A, Mukhtar T, Eze U.C, Simoneau C.R, Perez Y, Mostajo-Radji M.A, Wang S, Velmeshev D, Jahan S, Kumar G.R, Pollen A.A, Crouch E, Ott M, Kriegstein A.R. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. Proc Natl Acad Sci U S A . 2022   doi: 10.1073/pnas.2122236119

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J Jr, Andino R, Wadford DA, Hanson C*, Doudna J,* Ott M*, Chiu CY*. Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Cell. 2022. doi: 10.1016/j.cell.2022.03.019.

Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2

Chen I, Longbotham J.E, McMahon S, Suryawanshi R, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg F.W , Hayashi J.M , Taha T.H, Lam V.L, Li Y, Yu Z, Titus E.W, Diallo A,  Oki J, Holden K, QCRG Structural Biology Consortium; Krogan N, Fujimori D, Ott MViral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. Cell Rep. 2022.  doi: 10.1016/j.celrep.2022.111088. Epub 2022 Jun 27

Identification of a Therapeutic Interfering Particle — a single-administration SARS-CoV-2 antiviral intervention with a high barrier to resistance

Sonali Chaturvedi, Gustavo Vasen, Michael Pablo, Xinyue Chen, Nathan Beutler, Arjun Kumar, Elizabeth Tanner, Sylvia Illouz, Donna Rahgoshay, John Burnett, Leo Holguin, Pei-Yi Chen, Blaise Ndjamen, Melanie Ott, Robert Rodick, Thomas Rogers, David M. Smith, Leor Weinberger, Identification of a Therapeutic Interfering Particle — a single-administration SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Cell, 2021, https://doi.org/10.1016/j.cell.2021.11.004.