COVID-19 (SARS-CoV-2) Archives : The Ott Lab

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Tsujino S, Tsuda M, Ito J, Deguchi S, Taha TY, Nasser H, Wang L, Rosecrans J, Suzuki R, Suzuki S, Yoshimatsu K, Ott M; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ikeda T, Takayama K, Sato K, Tanaka S, Tamura T, Fukuhara T.

2025 May 30:2025.05.28.656516. doi: 10.1101/2025.05.28.656516. PMID: 40502047; PMCID: PMC12154822.

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zapatero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Matsui Y, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz RJ, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS.

2025 Apr 25;11(17):eadt7836. doi: 10.1126/sciadv.adt7836. Epub 2025 Apr 23. PMID: 40267184; PMCID: PMC12017303.

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

Taha TY, Ezzatpour S, Hayashi JM, Ye C, Zapatero-Belinchón FJ, Rosecrans JA, Kimmerly GR, Chen IP, Walcott K, Kurianowicz A, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Whittaker GR, Martinez-Sobrido L, Aguilar HC, Ott M.

2025 Mar 31;21(3):e1013020. doi: 10.1371/journal.ppat.1013020. PMID: 40163530; PMCID: PMC11981139.

Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

Rosas-Lemus M, Minasov G, Brunzelle JS, Taha TY, Lemak S, Yin S, Shuvalova L, Rosecrans J, Khanna K, Seifert HS, Savchenko A, Stogios PJ, Ott M, Satchell KJF.

2025 Mar;34(3):e70050. doi: 10.1002/pro.70050. PMID: 39969084; PMCID: PMC11837046.

Structure-based discovery of a highly bioavailable, covalent SARS-CoV-2 major protease inhibitor with pan-coronavirus activity and potent in vivo efficacy.

Detomasi TC, Degotte , Huang S, Suryawanshi RK, Diallo A, Lizzardo L, Zapatero-Belinchon FJ, Taha TY, Li J, Richards A, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz J, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS.

[Preprint] 2025, January 18. 2025.01.16.633443; doi: https://doi.org/10.1101/2025.01.16.633443

The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.

Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O’Leary PC, Taha TY, Zapatero-Belinchón FJ, McCavittMalvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Richards AL, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS.

2024 Aug 29:2024.08.08.606661. doi: 10.1101/2024.08.08.606661. PMID: 39149230; PMCID: PMC11326214.

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

Taha TY, Ezzatpour S, Hayashi J, Ye Chengjin, Zapatero-Belinchon FJ, ROsecrans JA, Kimmerly GR, Kimmerly GR, Chen IP, Walcott K, Kurianowicz, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Martinez-Sobrino L, Aguilar HC, Ott M.

[Preprint] 2024, December 30. 2024.12.30.628795; doi: https://doi.org/10.1101/2024.12.30.628795

Fibrin drives thromboinflammation and neuropathology in COVID-19.

Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K.

2024 Sep;633(8031):905-913. doi: 10.1038/s41586-024-07873-4. Epub 2024 Aug 28. PMID: 39198643; PMCID: PMC11424477.

Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.

Li L, Matsui Y, Prahl MK, Cassidy AG, Golan Y, Jigmeddagva U, Ozarslan N, Lin CY, Buarpung S, Gonzalez VJ, Chidboy MA, Basilio E, Lynch KL, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens J, Rincon M, Myatt L, Taha TY, Montano M, Ott M, Greene WC, Gaw SL.

2024 Aug 27;9(1):156. doi: 10.1038/s41541-024-00948-3. PMID: 39191763; PMCID: PMC11349990.

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR.

2024 Aug 2;10(31):eadm8836. doi: 10.1126/sciadv.adm8836. Epub 2024 Jul 31. PMID: 39083602; PMCID: PMC11290487.

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Publication Category: COVID-19 (SARS-CoV-2)