The Ott Lab publishes novel research on SARS-CoV-2 variants Read More

Blog

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

Khalid, M. M., Chen, I. P., Soveg, F. S., Taha, T. Y., Tabata, T., Suryawanshi, R. K., Syed, A. M., Ciling, A., McCavitt-Malvido, M., Schulze-Gahmen, U., Hayashi, J., Kim, I. J., Fong, S. W., Batra, J., Kumar, G. R., Renia, L., Ng, L. F., Krogan, N. J., Doudna, J. A., Verdin, E., … Ott, M. (2026).

bioRxiv : the preprint server for biology, 2024.03.05.583578. https://doi.org/10.1101/2024.03.05.583578

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

Lizzadro, L., Li, J., Taha, T. Y., Degotte, G., Detomasi, T. C., Zapatero-Belinchon, F. J., Hantz, E. R., Huang, S., Matsui, Y., Henderson, W. R., McCann, J. T., Montano, M., Rosecrans, J., Torres Pomares, D. F., McGovern, B. L., Diaz-Tapia, R., Benjamin, J., Gordon, M. E., Suazo, I. D., Settineri, N. S., … Renslo, A. R. (2026).

Journal of medicinal chemistry, 69(2), 1530–1551. https://doi.org/10.1021/acs.jmedchem.5c03015

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Suryawanshi, R. K., Jaishankar, P., Correy, G. J., Rachman, M. M., O’Leary, P. C., Taha, T. Y., Matsui, Y., Zapatero-Belinchón, F. J., McCavitt-Malvido, M., Doruk, Y. U., Stevens, M. G. V., Diolaiti, M. E., Jogalekar, M. P., Chen, H., Richards, A. L., Kongpracha, P., Bali, S., Montano, M., Rosecrans, J., Matthay, M., … Fraser, J. S. (2025).

eLife, 14, RP103484. https://doi.org/10.7554/eLife.103484

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

Jaishankar, P., Correy, G. J., Matsui, Y., Togo, T., Rachman, M. M., Stevens, M. G. V., Hantz, E. R., Zheng, J., Diolaiti, M. E., Montano, M., Taha, T. Y., Rosecrans, J., Pampel, J., Krogan, N. J., Shoichet, B. K., Ashworth, A., Ott, M., Fraser, J. S., & Renslo, A. R. (2025).

bioRxiv : the preprint server for biology, 2025.10.11.681833. https://doi.org/10.1101/2025.10.11.681833

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Gordon M, Malpotra S, Cupic A, Kehrer T, Moen JM, Winters DM, Rojc A, Mena I, Aslam S, Martinez-Romero C, Conde Viñas I, Khalil Z, Farrugia K, Banerjee A, Tussia-Cohen D, Santos MD, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, Felipe CS, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi R, Ibáñez C, Juste J, Pache L, Taha TY, Jouvenet N, Verba KA, Fraser JS, Demeret C, Stroud RM, van Bakel H, Ott M, Hagai T, Polacco B, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ.

bioRxiv [Preprint]. 2025 Jul 28:2025.07.26.666918. doi: 10.1101/2025.07.26.666918. PMID: 40766693; PMCID: PMC12324264.